All-in-one target-cell-specific magnetic nanoparticles for simultaneous molecular imaging and siRNA delivery.
نویسندگان
چکیده
Cancer-cell-targeted gene silencing was observed with a magnetic-nanoparticle platform (MEIO, magnetism-engineered iron oxide) on which a fluorescent dye, siRNA, and a RGD-peptide targeting moiety were attached (see picture). The different functionalities enable the macroscopic (magnetic resonance) and microscopic (fluorescence) imaging of target cells. This system may be suitable for concurrent diagnostic and therapeutic applications.
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عنوان ژورنال:
- Angewandte Chemie
دوره 48 23 شماره
صفحات -
تاریخ انتشار 2009